eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
1/2024
vol. 41
 
Share:
Share:
abstract:
Original paper

Comparative efficacy of combined antihistamine and montelukast therapy in adult patients with atopic dermatitis

Kristina R. Jamalyan
1
,
Helen G. Azaryan
2

  1. Department of Immunology and Allergology, National Institute of Health, Republic of Armenia
  2. “Helios” Medical Center, Yerevan, Republic of Armenia
Adv Dermatol Allergol 2024; XLI (1): 32-40
Online publish date: 2024/03/15
View full text Get citation
 
Introduction:
Atopic dermatitis (AD) is one of the most common chronic skin conditions affecting about 20% of children and 5% of adults. However, the studies assessing novel therapies for AD have been focused mainly on paediatric patients and only few studies have involved adult participants.

Aim:
To compare the treatment outcomes between the antihistamine monotherapy and combined intervention with an antihistamine agent and a cysteinyl leukotriene receptor antagonist in adult patients with atopic dermatitis.

Material and methods:
Patients were randomized into two groups to receive 5 mg oral desloratadine or the combined therapy with 5 mg oral desloratadine and 10 mg montelukast. Both groups were also administered topical treatment using the same protocol (topical Elocon and moisturizer). To estimate the efficacy of the implemented therapy methods, different skin health scores (SCORAD, GISS, EASI, PPNRS and DLQI) and skin functional assessment outcomes (corneometry, pH and transepidermal water loss) were evaluated before and after the treatment.

Results:
Significant differences were revealed in compared measurement results for scales of the Extent and Severity of Eczema assessment, Global Individual Signs Score, Eczema Area and Severity Index, Pruritus Numerical Rating Scale, Dermatology Life Quality Index and Skin Functional Properties (p > 0.05).

Conclusions:
Comparison of data presenting the therapy outcomes in two groups showed that administration of the combined therapy was significantly more effective compared to the antihistamine monotherapy. The results revealed considerable efficacy of the combined therapy reinforced by the use of cysteinyl leukotriene receptor antagonist, montelukast.

keywords:

atopic dermatitis, adult patients, viral complication, antihistamine, montelukast, combined, treatment

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.