eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
1/2024
vol. 41
 
Share:
Share:
abstract:
Original paper

Levels of serum inflammatory cytokines and their correlations with disease severity in patients with chronic spontaneous urticaria

Wenming Zeng
1
,
Jining Xia
1
,
Qiming Zeng
2

  1. Department of Dermatology, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang Province, China
  2. Department of Tuina, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, Yunnan Province, China
Adv Dermatol Allergol 2024; XLI (1): 85-90
Online publish date: 2024/03/15
View full text Get citation
 
Introduction:
Inflammation is crucial in the pathogenesis of chronic spontaneous urticaria (CSU). Investigating the correlation between levels of serum inflammatory cytokines (SICs) and the severity of CSU is of great significance for understanding the disease mechanism and finding effective treatment strategies.

Aim:
In this context, this work was developed.

Material and methods:
This work involved a researchy group (Res group) of 114 patients with CSU and a control group (Ctrl group) of 100 healthy individuals. SICs including leukotriene B4 (LTB4), leukotriene C4 (LTC4), interleukin (IL) 4 (IL-4), IL-17, IL-31, and tumor necrosis factor-g (TNF-g), of patients in different groups were measured and compared. Furthermore, the correlations between each SIC and pruritus severity, duration of pruritus, urticaria activity, and quality of life (QOL) were compared among the patients in different groups.

Results:
The Res group exhibited higher levels of LTB4, LTC4, IL-4, IL-17, and IL-31 but lower levels of TNF-g. Great differences (p < 0.05) were found in IL-4, IL-17, and IL-31 among the patients with different pruritus severity, and positive correlations were observed between IL-17 and IL-31 levels and urticaria activity in the patients (p < 0.05). Additionally, levels of IL-4 and IL-31 exhibited a positive association to QOL scores in the patients, with obvious differences (p < 0.05).

Conclusions:
IL-4, IL-17, and IL-31 showed the strongest correlation with the severity of CSU, which may be attributed to their involvement in immune, inflammatory, and pruritic reactions, exacerbating the disease condition.

keywords:

chronic spontaneous urticaria, serum inflammatory cytokines, severity of disease, interleukin 31, interleukin 17

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.